SOD3 and Parkinson disease: To further confirm that anti-Parkinson’s activities of HLEA-P1 is mediated by de-activating IIS pathway which, in turn, allows DAF-16 to enter the nucleus and activate its target genes, we measured the expressions of mRNAs of sod-3, hsp-16.1, hsp-16.2, and hsp-12.6 in C. elegans PD models.