To verify the up-regulation of p53 by Nutlin-3 and RG-7112 in A549-hACE2, we evaluated by Western blotting p53 protein levels and other proteins regulated by p53, at the time of SARS-CoV-2 infection (24 h after initiation of treatment, Figures 3A,B) and 48 h post-infection (72 h of treatments, Figures 3C–F). Here, TP53 is linked to infection.