In response to viruses, p53 has a recognized role in contrasting the infection principally through cell death induction as a part of the antiviral innate immunity, together with the regulation of cytokine production and nuclear factor kappa light chain enhancer of activated B cells, NF-kB signaling (Muñoz-Fontela et al., 2016; Milani et al., 2022). This evidence concerns the gene NFKB1 and infection.