Human β-defensin 2 (HBD-2), Claudin-3, high-mobility group box-1 protein (HMGB-1), and resistin-like molecule β (Relmβ) are potential biomarkers in intestinal inflammation, and they have been proposed as such in the diagnosis of NEC (10–15). The gene discussed is HMGB1; the disease is necrotizing enterocolitis.