CLOCK and Alzheimer disease: Moreover, the disruption in the normal organization of clock genes can induce the risks of neurological disorders, including major depression disorder (MDD), Schizophrenia, Parkinson’s disease (PD), Alzheimer’s disease (AD), Prader–Willi syndrome (PWS), Smith–Magenis syndrome (SMS), autism spectrum disorders (ASDs), and attention-deficit hyperactivity disorder (ADHD) (Khan et al., 2018; Logan and McClung, 2019).