Major inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) have the ability themselves to potentiate inflammation and are known to be associated with various inflammatory diseases such as hypertension, type 2 diabetes, and cardiovascular disease (Kany et al., 2019; Martin-Rodriguez et al., 2015). This evidence concerns the gene IL1B and hypertensive disorder.