The majority of the candidates identified as “very probably H-NOX”, play important roles in the immune system and are implicated in cancers such as ADAMTS-16 which is upregulated by cancer-induced methylation in colorectal, lung, and oral cancers, a cervical cancer antigen interacting with high-risk HPV E6 proteins, the breast cancer antigen NY-BR38, and the 5T4 oncofetal antigen [146], [147], [148]. The gene discussed is TPBG; the disease is cancer.