FASN and liver disorder: The development of liver disease caused by a high-fat diet may be worsened as a result of this effect, which may include mechanisms such as an increase in oxidative stress and cell death in the liver, as well as a decrease in the activation of AMPK, fatty acid synthase (de novo liver steatosis), and the 1-c sterol response element binding protein, all of which are linked to the development of liver disease (6, 16).