It has been shown that inhibition of MAPK signal transduction by GZMB silencing can reduce the expression of inflammatory factors, apoptosis-related factors (Bcl-2 and caspase) and angiogenesis-related factors (VEGF and bFGF), thus reducing the synovial tissue hyperplasia and articular cartilage tissue damage associated with RA (16). This evidence concerns the gene GZMB and rheumatoid arthritis.