SCR-3 has an established regulatory role in lymphoproliferation: Contrary to its proliferative role in cancer, SRC-3 selectively inhibits the proliferation of lymphoid cells, allegedly through its physical interaction with IKK, which prevents the phosphorylation of IκB that then inhibits NF-κB-mediated proliferative and anti–apoptotic genes (74). Here, NCOA3 is linked to cancer.