CD4 and infection: Accordingly, naïve Tregs (CD4+ CD25high CD127low CD45RA+ CD62L+) and effector memory Tregs expressing CD45RA (TEMRA; CD4+ CD25high CD127low CD45RA+ CD62L-) were more frequent, whereas central memory (CD4+ CD25high CD127low CD45RA- CD62L+) and effector memory (CD4+ CD25high CD127low CD45RA- CD62L-) Tregs were lower in patients 12 weeks post-infection (62).