IL10 and colitis: The PD results observed in this study are in contrast with preclinical data where EDP1066 induced IL-10 production in in vitro human dendritic cell (DC) cultures, without significant induction of pro-inflammatory cytokines (unpublished data), and EDP1066 significantly reduced KLH- and ovalbumin-induced ear inflammation in mice and improved intestinal pathology and weight loss in an acute dextran sulfate sodium-induced colitis mouse model (unpublished data).