For example, high doses of glucocorticoids significantly increase the risk of atherosclerosis and thrombosis (43, 44); immunosuppressants including azathioprine, cyclophosphamide, and anti-tumor necrosis factor drugs may help suppress thrombosis by controlling systemic inflammation and disease activity (43); interestingly, some immunosuppressive agents such as JAK inhibitors have been reported to have some adverse risk of thrombosis in RA treatment (45). The gene discussed is TNF; the disease is rheumatoid arthritis.