IGFBP3 and metabolic dysfunction-associated steatotic liver disease: This finding was consistent with the results of previous studies (32, 33) that showed that IGFBP3 was the most pronounced downregulated protein in patients with Child-Pugh C. A decrease in plasma IGFBP3 levels has also been observed in patients with other chronic liver disease-non-alcoholic fatty liver disease (NAFLD) (34).