SOX2 and neoplasm: ,20 A knockdown of FTO decreased the proliferation, migration, and expression of epithelial-mesenchymal transition (EMT) protein (Sox2, Slug, and ZEB1) of the OSCC and hypopharyngeal squamous cell carcinoma cell lines.9, 10, 11,19 The results suggest a role of the ALKBH5 in tumor-cells proliferation and the involvement of FTO in the proliferation and EMT process of the dysplastic cells in the OSCC, esophageal, and hypopharyngeal squamous cell carcinoma.