,20 A knockdown of FTO decreased the proliferation, migration, and expression of epithelial-mesenchymal transition (EMT) protein (Sox2, Slug, and ZEB1) of the OSCC and hypopharyngeal squamous cell carcinoma cell lines.9, 10, 11,19 The results suggest a role of the ALKBH5 in tumor-cells proliferation and the involvement of FTO in the proliferation and EMT process of the dysplastic cells in the OSCC, esophageal, and hypopharyngeal squamous cell carcinoma. This evidence concerns the gene SOX2 and hypopharynx squamous cell carcinoma.