Due to the fact that antigen B modulates immune responses, stimulates anti‐inflammatory responses, and converts inflammatory macrophages (M1) into anti‐inflammatory macrophages (M2) (Siracusano et al., 2009), in the current study, we investigated the anti‐inflammatory effects of antigen B on the EAE‐induced immune and electrophysiological alterations as an animal model of MS. The gene discussed is PPIB; the disease is myeloid sarcoma.