Through three independent ccRCC datasets, (TCGA-KIRC, JAPAN-KIRC and Cacner cell-cohort), containing 1439 ccRCC samples, we found that the cuproptosis score calculated by ssGSEA was significantly correlated with the cGAS-STING-related signature, including TMEM173/STING, TBK1, MB21D1/cGAS and IRF3, except for TBK1 in Motzer’s cohort (Fig. 13D). The gene discussed is IRF3; the disease is nonpapillary renal cell carcinoma.