As shown in Fig. 1A, most copper induced cell death genes were downregulated in various cancers, such as FDX1 in cholangiocarcinoma (CHOL); LIAS and LIPT1 in bladder cancer (BLCA); PDHB in glioblastoma (GBM) and kidney chromophobe cancer (KICH). The gene discussed is PDHB; the disease is cancer.