SPIB and breast cancer: We also investigated the effects of conventional chemotherapy on risk genes, and using the DREAM database, we found significant changes in the expression levels of many genes, including CCL19 (FC = 0.96, P = 0.0192), SPIB (FC = 0.93, P = 0.00722) and IGKC (FC = 0.96, P = 0.0144) in BC patients treated with drugs (Fig. 11B).