TIM-3 plays an immunosuppressive role in the immune microenvironment, not only inducing depletion of CD8 + T cells [78], but also promoting activation of Treg cell [79] and massive proliferation of MDSCs [80], implying that LDs upregulation may inhibit the antitumor immune response in HCC. This evidence concerns the gene CD8A and hepatocellular carcinoma.