While 14 articles mentioned the BC stage (nine cases of metastatic BC or advanced BC and five cases of early stage BC) and ten articles mentioned that their target population is patients with HER-2 positive BC [26, 28, 30–33, 37, 38, 42, 43], and three articles mentioned that their target population is HER-2 negative [34, 39, 41]. Here, ERBB2 is linked to breast cancer.