In addition, SRC kinase can also regulate the PI3K/AKT signaling through either inhibitory phosphorylation of PTEN [80] or activating phosphorylation of PI3K [81], AKT [33, 82, 83] or SGK1 [84], thereby regulating multiple events of BC development (Fig. 4 and Table 1). This evidence concerns the gene AKT1 and breast cancer.