PGRN has been considered a unique risk protein that sits atop the regulating cascade controlling brain health, and PGRN dysfunction is an important cause of several neurodegenerative diseases through the resulting dysregulation of neuronal survival and function and the autophagy–lysosomal pathway as well as neuroinflammation [34, 61]; however, the precise mechanisms underlying the role of PGRN in neurodegenerative diseases are still not fully known. The gene discussed is GRN; the disease is neurodegenerative disease.