Based on this evidence, our present results showed that PGRN deficiency exerts antidepressant effects at least partially by attenuating astrocyte- and microglial activation-associated inflammatory responses and neuroplasticity alterations occurring in the NAc in the NAc neuroinflammation-induced depressive-like phenotype, which is opposite of the findings of other studies on brain injuries. The gene discussed is GRN; the disease is brain injury.