In addition to the BDNF expression and neuroplasticity changes in the NAc observed in PGRNKO mice, we found that the levels of the astrocyte and inflammatory cytokines IL-6 and IL-10 were enhanced in the NAc these mice, suggesting that PGRN deficiency results in astrocyte activation and inflammatory responses in the NAc, which in turn results in NAc neuroplasticity alterations and FTD-like behaviors. Here, GRN is linked to frontotemporal dementia.