In the same direction, a previous study has shown that circulating IL-6 was increased in PGRN-mutated FTD patients as compared to both PGRN non-mutated FTD patients and controls; also, in vitro study verified by IL-10 neutralizing antibody indicated that macrophages from PGRNKO mice contribute to hyperinflammatory phenotype through affecting 1L-10 production [62, 63]. Here, IL6 is linked to frontotemporal dementia.