SLC5A2 and heart failure: Similarly, Muthiah et al. conducted a meta-analysis of two largest trials [DELIVER and Empagliflozin Outcome Trial in Patients with Chronic Heart Failure with Preserved Ejection Fraction (EMPEROR-Preserved)] and implied that SGLT2 inhibitors significantly reduced the risk of composite cardiovascular death or hospitalization for heart failure, but not all-cause death and cardiovascular death [18].