MAPT and early-onset autosomal dominant Alzheimer disease: There were no evident changes in the measured CSF AD markers, which all were consistent with Alzheimer’s disease (the Aβ42/Aβ40 ratio < 0.0646, phosphor-tau181 > 42.4 pg/ml, and total tau > 342 pg/ml) nor did these correlate with plasma 24HC levels.