A moderate negative correlation between TACR3 DNAm and ad was observed in the all PAE group (cg16461251: r = −0,403, P = 0.041 and cg18538958: r = −0.395, P = 0.046, n = 26, Spearman’s rank correlation) and a strong negative correlation in the early PAE subgroup (cg18538958: r = −0.762, P = 0.028, n = 8, Spearman’s rank correlation). Here, TACR3 is linked to pulmonary artery enlargement.