To elucidate the biological functions of CDKN2A, TIGIT, COL4A4, PXDN, CHODL, LMO3, KCNJ12, L1CAM, and EPHB1 in UCEC tumor cells, we knocked down the expression of the 9-gene signature using shRNA or the negative control in Ishikawa cell lines to assess cell proliferation, migration, and invasion in vitro (Fig. 7A). This evidence concerns the gene LMO3 and neoplasm.