To elucidate the biological functions of CDKN2A, TIGIT, COL4A4, PXDN, CHODL, LMO3, KCNJ12, L1CAM, and EPHB1 in UCEC tumor cells, we knocked down the expression of the 9-gene signature using shRNA or the negative control in Ishikawa cell lines to assess cell proliferation, migration, and invasion in vitro (Fig. 7A). Here, TIGIT is linked to neoplasm.