Similarly, the present results demonstrated that pharmacological inhibition of the NF-κB pathway not only ameliorated the changes in fission proteins (Drp1 and Fis1) and fusion proteins (OPA1, Mfn1 and Mfn2) but also improved mitochondrial function by rescuing MMP and ameliorating ROS production in the intestinal epithelium during sepsis. The gene discussed is NFKB1; the disease is Sepsis.