Excessive fission and deficient fusion in mitochondria during sepsis result in the accumulation of mitochondrial fragmentation, which induces the production of ROS and permeabilizes the outer membrane, damaging mitochondrial function (Chan 2012).Furthermore, impaired mitochondria release cytochrome c, an essential component of the respiratory chain, into the cytosol to trigger apoptosis (Borutaite 2010; Kalpage et al. 2019). This evidence concerns the gene CYCS and Sepsis.