The percentage of IRF8+ M-MDSC (Extended Data Fig. 8c) and TAMs (Extended Data Fig. 8d) and the expression of CD80 and CD86 in TAMs (Extended Data Fig. 8e) was increased in Pdcd1f/fLysMCre tumor-bearing mice compared to Pdcd1f/f tumor-bearing mice. Here, IRF8 is linked to neoplasm.