EZH2 and neoplasm: Over-representation and gene set enrichment analysis (GSEA) indicated that relative to those isolated from Shp2f/f tumor-bearing mice, gene expression profiles of myeloid cells from Shp2f/fLysMCre tumor-bearing mice were enriched for processes involved in the regulation of PRC2-EZH2 targets, phagosome formation, myeloid cell differentiation, neutrophil-mediated immunity, Notch signaling and HOXA targets, and were dominated by functions of antigen processing and presentation, myeloid cell migration, mitosis and autophagy (Fig. 4k,l and Extended Data Fig. 2a).