Based on the expression of CD44, CD8+ T cells in tumor-draining lymph nodes (dLN) of Shp2f/fLysMCre mice had a more activated state compared to their counterparts in Shp2f/fLckCre and control Shp2f/f mice (Fig. 1b,c; gating strategy, Supplementary Fig. 1). This evidence concerns the gene CD8A and neoplasm.