We noted increased expression of Nos2 (Fig. 5b), which characterizes inflammatory macrophages differentiated from Ly6Chi monocytes25; STING (encoded by Tmem173) (Supplementary Table 2), a pattern recognition receptor that transmits signals activating IFN type I responses26; IFN type I-induced proinflammatory genes Ifit2, Ifit3 and Cmpk2 (Fig. 5b); and TLRs and TLR downstream signaling mediators such as Unc93b1 and Wdfy1 (Fig. 5b,c and Supplementary Table 2) in TAMs of Shp2fl/flLysMCre tumor-bearing mice, indicating an enhanced proinflammatory program. This evidence concerns the gene CMPK2 and neoplasm.