There was an increase in number of CD4+ and CD8+ TEF cells (Fig. 3g,h) and an increase in the fraction activated CD44+CD8+ T cells (Fig. 3i,j) in dLN, a systemic increase of CD4+ and CD8+ TEF and TCM-like cells (Fig. 3k,l) and enhanced T cell activation (Fig. 3m,n) in the spleen of Shp2f/fLysMCre compared to Shp2f/f MC17-51 tumor-bearing mice. Here, CD4 is linked to neoplasm.