Tumor PMN-MDSC in Shp2f/fLysMCre mice had higher expression of IFN-γ than their counterparts in Shp2f/f mice (Fig. 4f,g), indicating that, in the context of cancer, deletion of SHP-2 switched the differentiation of myeloid cells toward proinflammatory neutrophils, and monocytes with enhanced antigen presentation and T cell costimulation capacity. This evidence concerns the gene PTPN11 and cancer.