CD44hiCD62Llo T effector cells (hereafter TEF cells) and CD44+CD62Lhi central memory T-like cells (TCM-like cells) from tumor-bearing Shp2f/fLysMCre mice had increased expression of IFN-γ (Fig. 1d), indicating a state of activation and effector function. This evidence concerns the gene CD44 and neoplasm.