Although a wide range of molecular alterations is known to cause HRD, previous studies have focused on BRCA1/2 mutations to detect HRD-specific AIs (HRD-AIs), potentially failing to detect non-BRCA associated HRD alterations while losing specificity to classify the HR-proficient (HRP) samples accurately. This evidence concerns the gene BRCA1 and hypoparathyroidism-retardation-dysmorphism syndrome.