BRCA1 and hypoparathyroidism-retardation-dysmorphism syndrome: Using prior knowledge and multi-omics data, we annotated 115 HRD samples harboring a somatic or germline mutation, gene deletion, or promoter hypermethylation in the BRCA1/2 or RAD51 paralog genes, and 29 HRP samples that did not harbor any of the alterations used to select the HRD samples, nor deletions in any other HR-related gene (Fig. 2a).