Regarding CD39 and CD73, we observed a significant increase in the B-ALL group of the expression level of CD39 and CD73, as well as in the frequency of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$${CD39}^{+}{CD73}^{+}$$\end{document}CD39+CD73+ double positive Breg cells. The gene discussed is ENTPD1; the disease is precursor B-cell acute lymphoblastic leukemia.