ADO and precursor B-cell acute lymphoblastic leukemia: In this context, purinergic signaling has emerged in recent years as an important pathway in cancer progression, where extracellular adenosine triphosphate (ATP) and adenosine (ADO) act as signaling molecules in various biological activities and modulate the function of tumor cells, even though it still receives little attention from the field of hematological neoplasms, especially B-ALL [11–14].