IGF1, POSTN, MMP7, ASPN, and CXCL14 were preliminarily selected as hub genes of PF by MCC, DMNC, MNC, Degree, EPC, BottleNeck, EcCentricity and Closeness 8 algorithms (Fig. 1D). The gene discussed is IGF1; the disease is pemphigus foliaceus.