SIRT2 and melanoma: For instance, the expression of SIRT2 is decreased in CC tissue compared with paired adjacent tissue, and SIRT2 expression in tumor tissue is negatively correlated with tumor size, and lymph node metastasis, which predicts favorable survival.471 For mechanistic studies, SIRT1 has been found to be overexpressed in HPV-infected CC cells and SIRT1 expression is correlated with poor clinical outcomes in CC.472 SIRT1 enables HPV-infected CC cells to continue growing by nullifying absent in melanoma 2 inflammasome-mediated immunity.