Inhibition of SIRT2 enhanced microglial activation and the release of pro-inflammatory cytokines via acetylation-dependent upregulation of NF-κB transcriptional activity.88 SIRT2 reduced the levels of pro-inflammatory cytokines and ameliorated the severity of arthritis by deacetylating the p65 subunit of NF-κB,89 further demonstrating the role of SIRT2 activation in suppression of the inflammatory response. This evidence concerns the gene NFKB1 and arthritic joint disease.