SIRT4 and neoplasm: At the molecular level, SIRT3 depletion inhibits EMT by lower E-cadherin expression, leading to tumor suppression.382 Sun et al. suggested that SIRT4 suppressed EMT through promoting E-cadherin expression in GC cells.383 Li et al. reported that SIRT3 was involved in the inhibitory effect of nicotinic alpha7 subtype of nicotinic acetylcholine receptors on platelet-derived growth factor-BB, an angiogenic factor, induced VSMC migration.