SIRT3 promotes the expression of MnSOD, and this regulation is crucial for the protective effect of SIRT3 on hyperoxia-induced ALI.643 SIRT3 can also diminish inflammation and mitigate endotoxin-induced ALI.63 Kurundkar et al. have shown that SIRT3-deficient mice (SIRT3−/−) develop more severe ALI compared to wild-type controls (SIRT3+/+). Here, SOD2 is linked to acute respiratory distress syndrome.