PCOS patients had higher SIRT1 levels than healthy controls923 and involvement of the SIRT1/AMPK axis in autophagy activation in PCOS.924 SIRT3 deficiency in granulosa cells of PCOS patients might potentially induce impaired oocytes in PCOS.925 Furthermore, previous studies only explored the association between SIRT1 and endometriosis. The gene discussed is SIRT1; the disease is endometriosis.