Oxidative stress and aging are important factors that regulate the osteogenic differentiation process, and these can also be regulated by SIRT1 and thus are anti-osteoporosis.945 For instance, SIRT1 overexpression increased osteoblast osteogenesis through FoxO3a deacetylation and oxidative stress inhibition.946 Overexpression of SIRT1 might also reduce oxidative stress through the FoxO1 and β-catenin signaling pathways.222 In addition, SIRT1 plays a protective role in osteoporosis by regulating bone metabolism. Here, FOXO3 is linked to osteoporosis.