SIRT5 and hepatocellular carcinoma: For example, Dang et al. found that SIRT5 promoted migration and invasion of HCC cells.385 The opposite findings were reported by Yao et al. in that the inhibition of SIRT5 increased migration and invasion of HCC in hypoxic microenvironments.386 This inconsistent phenomenon might be attributed to the hypoxic status of tumor microenvironments.