AKR1C1 and cancer: STAT3 is an important protein for regulating cell invasion and migration.376,377 STAT3 has been shown to affect EMT in several cancers.378 Previous studies have shown that SIRT2 can deacetylate Aldo-keto reductase family 1 member C1 (AKR1C1), which is a member of the human aldo-keto reductase protein family that catalyzes NADP + -dependent reduction.