For example, early SIRT2 inhibition prevented neuroinflammation evidenced by reduced levels of glial fibrillary acidic protein, IL-1β, IL-6 and TNF-α and by increased levels of glutamate receptor subunits GluN2A, GluN2B and GluA1; however, SIRT2 inhibition was unable to reverse cognitive decline or neuroinflammation.67 In this case, SIRT2 exhibited a temporary proinflammatory effect. Here, SIRT2 is linked to Mental deterioration.