Based on a mouse model of cholestatic liver disease, intestine-specific deletion of SIRT1 impaired systemic bile acid homeostasis.707,708 In an in vivo model of cholestatic disease, SIRT1-overexpressing myeloid cells with macrophage activation contributed to liver injury and fibrosis by activating the inflammasome and attenuating autophagy.709 Therefore, the role of SIRTs might be varied in different liver diseases. The gene discussed is SIRT1; the disease is Cholestatic liver disease.