Growing evidence has suggested that mitochondrial dysfunction is a major contributor to AKI.151,254,883–885 SIRT3-5 proteins, which are expressed in mitochondria, seem to play an important protective role in AKI.886 Among these, the protective role of SIRT3 has been reported to be related to improving mitochondrial function and ultimately improving apoptosis and eliminating ROS.151,254,883–885 For example, a sepsis-induced AKI model was constructed in wild-type and SIRT3 systematic KO mice. This evidence concerns the gene SIRT3 and acute kidney injury.