SIRT1 and breast cancer: SIRT1 plays a critical role in regulating EMT-associated programming and thus, consequently, eliciting BC invasion and metastasis in patients with triple-negative BC.401 SIRT1 expression suppresses BC metastasis by reducing EMT, and invasiveness in nude mice.402 The effect of SIRT1 modulation on EMT in breast cancer-related cancer stem cells has also been observed.