Similar protective effects during heart failure have also been observed in SIRT6.511 SIRT6 expression is significantly decreased in the hearts of patients with chronic heart failure as well as animal models of heart failure.527 SIRT6 overexpression increases the survival of transverse aortic constriction-induced heart failure mice, which might be associated with telomerase upregulation, such as telomerase reverse transcriptase and telomeric repeat binding factor 1.540. This evidence concerns the gene TERF1 and heart failure.