MC2494 has been reported as a micromolar pan-SIRT inhibitor and regulated mitochondrial function in a leukemia cell line.1037 As the result of cambinol manipulation, MC2141 was identified in 2010 and was the prototype of a class of benzodeazaoxaflavins that inhibited SIRT1/2 in the low micromolar range.1038 Tripos 360702 showed SIRT2 inhibitory activity with IC50 values of 51 μM in a test, and could be considered a novel inhibitor of SIRT2.1039. The gene discussed is SIRT2; the disease is leukemia.