SIRT7 and acute kidney injury: For example, SIRT5 regulates the balance of mitochondrial versus peroxisomal fatty acid oxidation in proximal tubular epithelial cells to protect against AKI,892 and SIRT6 overexpression inhibited apoptosis induced by LPS and promoted autophagy in HK-2 cells.312 Previous studies found that SIRT7 deficient mice were protected against AKI, suggesting that this HDAC promotes tubular damage and kidney inflammation.893