SIRT1 and idiopathic pulmonary fibrosis: According to the study performed by Zeng et al., SIRT1 expression was significantly increased in lungs from patients with IPF, as well as in lungs from bleomycin-induced LF mouse models.610 Nevertheless, SIRT1 activation or overexpression attenuates LF through regulation of canonical TGF-β1/p300 signaling.