SIRT2 and Mental deterioration: AD is the most common neurodegenerative disorder that is associated with memory deficit and global cognitive decline.735,736 It is a brain disorder associated with gradual weakening of neurocognitive functions, neuroinflammation, and impaired signaling pathways.737 The SIRT proteins associated with AD mainly include SIRT1, although mitochondrial SIRTs represented by SIRT3 have also been the focus of research, as well as SIRT6 and SIRT2 that are located in the nucleus and cytosol, respectively.