SIRT1 knockdown inhibits EMT, cell migration, and TGF-β signaling in keratinocytes.370 Furthermore, SIRT1 activates downstream PI3K/Akt and Notch signaling pathways, which alleviates H9c2 cell injury induced by hypoxia, via promoting cell proliferation, migration and invasion, and by inhibiting apoptosis.371 In non-small cell LC (NSCLC), the SIRT1-mediated AMPK/mTOR signaling pathway could promote A549 and H1299 cell proliferation, invasion and apoptosis.372. This evidence concerns the gene SIRT1 and non-small cell lung carcinoma.