SIRT1 and coronary artery disorder: CAD is the result of atherosclerotic plaque development in the walls of coronary arteries.561 It is one of the most common causes of death in the developed countries and is responsible for about one in every five deaths.562 Current studies on the role of SIRTs in CAD mainly focus on SIRT1, which has a protective effect on CAD by regulating some crucial biological processes, such as oxidative stress, inflammation, cell apoptosis, and cell proliferation.