SPP1 and lung adenocarcinoma: SIRT1 upregulated by SNHG10 suppresses NSCLC cell proliferation, as a tumor suppressor.420 Overexpression of SIRT1 protects NSCLC cells against osteopontin-induced NF-κB p65 acetylation and EMT, thus attenuating OPN-induced cell proliferation, migration and invasion.421 However, SIRT1 upregulated by circ_0001946, could promote cell growth in lung adenocarcinoma by activating the Wnt/β-catenin signaling pathway.422 SIRT2 and SIRT6 have been shown to exert both pro- and anticarcinogenic effects in the process of LC.