Knockdown of SIRT3 compromises the neuroprotective effects of pituitary adenylate cyclase activating polypeptide in AD, and this effect was reversed by overexpression of SIRT3.757 SIRT3 expression mirrors the spatiotemporal deposition of Aβ in an AD mouse model and is also upregulated in the temporal neocortex of patients with AD.758. This evidence concerns the gene ADCYAP1 and Alzheimer disease.