Previous studies have shown that SIRT7 has a positive role in regulating cell proliferation.355 Upregulation of SIRT7 protects against the proliferation of vascular smooth muscle cells (VSMCs) in atherosclerosis.355 Similarly, SIRT7 deficiency attenuates VSMC proliferation, thus attenuating neointimal formation following vascular injury.356 Moreover, SIRT7 depletion inhibits cancer cell proliferation by suppressing AR signaling and activating p38MAPK.318,357. This evidence concerns the gene SIRT7 and atherosclerosis.