SIRT1-mediated p21-Activated kinase 1-deacetylation at K420 hinders autophagy and glioblastoma growth.480 Besides, SIRT6 suppresses glioma cell growth via induction of apoptosis, inhibition of oxidative stress, and inhibition of the activation of the Janus kinase 2/STAT3 signaling pathway.478 On the contrary, SIRT3 and SIRT7 are reported to play positive roles in the development of glioma. The gene discussed is STAT3; the disease is central nervous system cancer.