For instance, overexpression of SIRT5 is correlated with poor prognosis in patients with CRC, while SIRT6 expression is related to improved survival.448,449 However, there still a need for further studies that make more clear analyses to verify the roles of SIRTs as biomarkers of CRC, such as receiver operating characteristic curve, sensitivity and specificity analyses. Here, SIRT5 is linked to colorectal carcinoma.