SIRT1 and Alzheimer disease: Another study showed that SIRT1 enhances the deacetylation of Beclin-1, thus suggesting the beneficial role of SIRT1 in promoting autophagy in AD neurodegeneration.270 The loss of function of SIRT2 either through AK1 (a specific SIRT2 inhibitor) or through SIRT2 KO recovers microtubule stabilization and improves autophagy.299