Human peripheral blood monocytes from patients with kidney stones showed decreased SIRT3 expression, but increased FoxO1 acetylation compared with the normal controls,51 and the protective effect of SIRT3 could be mediated by activation of the nuclear factor erythroid 2-related factor/heme oxygenase-1 pathway.912 A previous study suggested that suppressing SIRT1 expression promoted calcium oxalate monohydrate-induced crystal-cell adhesion and exacerbated cell injury.913. The gene discussed is SIRT1; the disease is nephrolithiasis.