Yu et al. have reported that there is positive feedback between SIRT1 and Zinc finger E-box binding homeobox 1, which enhances EMT of osteosarcoma.369 SIRT1 induces deacetylation of Beclin-1 and then accelerates autophagic degradation of the epithelial marker E-cadherin, further promoting EMT in melanoma cells.271 Epidermal SIRT1 plays a role in wound repair. Here, SIRT1 is linked to melanoma.