SIRT6 and central nervous system cancer: Glioma is the most common and malignant primary tumor of the central nervous system, with a poor prognosis, especially glioblastoma.474 SIRT1 and SIRT7 are upregulated,475,476 while SIRT3 and SIRT6 are downregulated in glioma tissues compared with normal or adjacent brain tissues.477,478 Glioma patients with higher SIRT1 or SIRT3 expression exhibit worse prognosis, whereas downregulation of SIRT5 is significantly correlated with shorter survival time in glioblastoma.