AR and Familial prostate cancer: SIRT7 plays an important role in tumor growth and metastases and immunohistochemical analysis of 93 specimens and bioinformatic analysis revealed that SIRT7 expression was positively associated with androgen receptor (AR) (in vivo).318 SIRT7 promotes prostate cancer autophagy indirectly via the AR signaling pathway.318 These results suggest that SIRT7 plays a positive role in promoting apoptosis.