SIRT1 and autoimmune hepatitis: For instance, an in vivo study showed that SIRT1-null mice developed an autoimmune-like disease related with the accumulation of immune complexes in the liver.700 Meanwhile, evidence also suggested that the activation of SIRT1 by resveratrol could protected against concanavalin A-induced autoimmune hepatitis in aged mice by repressing the expression of p66shc.