SIRT1 and SIRT6 deacetylate hnRNP A1 to suppress glycolysis and growth in HCC.440 SIRT6, stabilized by ubiquitin-specific peptidase 48, attenuates HCC glycolysis and impedes metabolic reprogramming, thereby hampering HCC malignancy.441 SIRTs can also play roles in modulation of the cell cycle in HCC, which are essential for tumor development. Here, USP48 is linked to hepatocellular carcinoma.