Ang II caused skeletal muscle atrophy, and SIRT3 deficiency enhanced Ang II-induced fiber type transformation and mitochondrial metabolic reprogramming, exacerbating skeletal muscle atrophy.961 The incidence of skeletal muscle atrophy and sarcopenia is increasing year by year.962 As the research on SIRTs in skeletal muscle physiological and pathological processes continues to advance, SIRTs could be used as targets for the prevention and treatment of skeletal muscle-related diseases. The gene discussed is AGT; the disease is Skeletal muscle atrophy.