SIRT1 and hepatocellular carcinoma: For instance, in colorectal cancer (CRC) cells, downregulation of SIRT1, by miR-34a transfection, increases the level of acetylated-p53 and inhibits cell migration and invasion.373 This situation is also found in HCC.374 Expression of SIRT1 can also be regulated by lncRNAs or circRNAs in a ceRNA-dependent manner.