In the case of inhibition of autophagy by SIRT5, mitochondrial size is increased and mitophagy decreased upon SIRT5 overexpression, whereas the opposite effect is observed in SIRT5-silenced cells or upon treatment with the SIRT5 inhibitor MC3482.302 However, SIRT5 could enhance autophagy in gastric cancer (GC) cells via the AMPK/mTOR pathway.309 Additionally, SIRT5-induced deacetylation of lactate dehydrogenase B triggers hyperactivation of autophagy; a key event in tumorigenesis.310 Succinyl-proteomics in brown adipose tissue of normal and SIRT5 KO mice. This evidence concerns the gene LDHB and gastric cancer.