For instance, overexpression of SIRT5 is correlated with poor prognosis in patients with CRC, while SIRT6 expression is related to improved survival.448,449 However, there still a need for further studies that make more clear analyses to verify the roles of SIRTs as biomarkers of CRC, such as receiver operating characteristic curve, sensitivity and specificity analyses. The gene discussed is SIRT6; the disease is colorectal carcinoma.