Therefore, apoptosis serves as a mechanism that suppresses the inflammatory response in alcoholic liver disease.677 These results suggest that high SIRT1 and SIRT7 levels in myeloid cells could be a primary event leading to enhanced inflammation, possibly owing to the deleterious consequence of apoptosis.677 Intestinal SIRT1 also exerted a partially harmful effect on alcoholic liver disease by intensifying hepatic ferroptosis and inflammation due to the imbalance of gut microbiota.678 Thus, it is logical to speculate that intestinal SIRT1 might act as a proinflammatory factor. The gene discussed is SIRT1; the disease is alcoholic liver diseases.