MAPK1 and breast cancer: SIRT3 has been found to affect p53 by disruption of the ERα–p53 interaction, and decrease proliferation, colony formation, and migration in BC cells.410 Notably, SIRT4 could exert its tumor-suppressive activity in BC though negatively regulating SIRT1 expression via repressing glutamine metabolism, which suggests a novel crosstalk between mitochondrial and nuclear SIRT proteins in BC progression.411 SIRT7 depletion inhibits tumor growth via activating p38/MAPK signaling.357