SIRT2 and ischemic stroke: The current study demonstrated the neuroprotective effects of SIRT2 inhibition in ischemic stroke and identified the downregulation of the Akt/FoxO3a and MAPK pathways as intermediary mechanisms that might contribute to the reduction in apoptotic cell death by SIRT2 inhibition.248 In clinical practice, SIRT2 might serve as a marker of acute ischemic stroke (AIS) risk and prognosis.