For example, SIRT1 attenuated kidney fibrosis by repressing HIF-2α;813 Endothelial SIRT1 deficiency induced nephrosclerosis through downregulation of matrix metalloproteinase-14, and restoration of matrix metalloproteinase-14 expression in SIRT1-depeleted mice improved the angiogenic and matrilytic functions of the endothelium, prevented kidney dysfunction, and attenuated nephrosclerosis;909 SIRT1 inhibited Ang II type 1 receptor and NF-κB expression in kidney fibroblasts and these mechanisms might play roles in alleviating UUO-induced damage.910. The gene discussed is EPAS1; the disease is nephrosclerosis.