TP53 and cancer: For example, miR-124 and miR-142 represses autophagy via targeting SIRT1 in cancer cells.291 Silencing of miR-150-5p increases autophagy by targeting the SIRT1/p53/AMPK pathway.292 miR-138-5p affects insulin resistance through inducing autophagy in HepG2 cells by regulating SIRT1, and overexpression of SIRT1 increases Beclin-1 and LC3 II/I levels, and the number of green fluorescent protein-LC3 dots, and decreases p62 level.293 miR-145 inhibition upregulates SIRT1 and attenuates autophagy via NF-κB-dependent Beclin-1.294