SIRT2 and cancer: AKR1C1 deacetylation further inhibits the transactivation of STAT3 target genes, thus suppressing migration in NSCLC cells and xenograft models.379 It has been reported that isocitrate dehydrogenase 1 (IDH1) affects cell migration in malignant tumors, such as glioblastoma.380 In human CRC, SIRT2-dependent IDH1 deacetylation represses CRC cell migration and invasion both in vitro and in vivo.381