At the molecular level, SIRT1 promotes the proliferation of endometrial cancer (EC) cells by reducing acetylation of LC3.272 SIRT1 deacetylates Rb protein in the Rb/ E2F transcription factor 1 (E2F1) complex, leading to dissociation of E2F1 and enhanced oligodendrocyte progenitor cell proliferation.326 SIRT1 directly regulates expression of transcription factor proteins, such as E2F1 and p53, subsequently promoting macrophage and HCC cell proliferation, respectively.327,328. The gene discussed is SIRT1; the disease is endometrial cancer.