SIRT2 and intervertebral disk degenerative disorder: For example, SIRT2 reversed the action of IL-1β by inhibiting the p53/p21 pathway, inhibited oxidative stress and cellular senescence, and thus prevented the degradation of nuclear myeloid cells in IDD.954 It was also found that SIRT3 maintains nucleus pulposus cell homeostasis to prevent IDD mainly by regulating mitochondrial oxidative stress levels.955,956 In addition, SIRT6 mainly inhibits the inflammatory response and cellular senescence during IDD by inhibiting the transcriptional activity of NF-κB pathways.957