NKX3-2 and Hypertension: For example, decreased urinary levels of SIRT1 can be seen as a non-invasive biomarker of early renal damage in hypertension.587 SIRT3 alleviates the development of hypertensive renal injury by suppressing EMT.588 Endothelial-specific deletion of SIRT6 significantly enhances blood pressure and exacerbates endothelial dysfunction and cardiorenal injury in experimental hypertension by targeting Nkx3.2-GATA5 signaling.589