SIRT1 and central nervous system cancer: For instance, SIRT1 inhibition increases the sensitivity of glioma cells for temozolomide via facilitation of intracellular ROS generation.475 In addition, CDK1-mediated SIRT3 activation could enhance mitochondrial function and contribute to adaptive radioresistance in glioma cells.481 Therefore, SIRTs are potential biomarkers for the prognosis and diagnosis of glioma and promising therapeutic targets.