For example, SIRT2 enhances N-Myc and c-Myc protein stability and promotes cancer cell proliferation.332 On the contrary, SIRT2 functions as an HDAC and inhibits proliferation of neuroblastoma cells, renal podocytes, and neuroblastoma cells.336 SIRT2 upregulation reduces cell proliferation in renal podocytes under high-glucose conditions.337 The opposite effect of SIRT2 on cell proliferation might be due to the different cell types, which might be the direction for future studies. This evidence concerns the gene MYC and cancer.