Macrophages obtained from SIRT3−/− mice show significant alterations in mitochondrial bioenergetic and redox homeostasis in association with proinflammatory phenotype characterized by NLRP3 inflammasome activation.63 Similarly, SIRT6 regulates macrophage polarization to alleviate sepsis-induced acute respiratory distress syndrome via dual mechanisms both dependent on and independent of autophagy.644. This evidence concerns the gene SIRT6 and acute respiratory distress syndrome.