SIRT1 and cancer: SIRT1 forms a molecular complex with Atg5, Atg7 and Atg8, and transiently increased expression of SIRT1 is sufficient to stimulate basal rates of autophagy.289 SIRT1 interacts with the Cullin 4B-Ring E3 ligase complex, which promotes autophagy of cancer cells.290 In conclusion, these molecules play important roles as the upstream or downstream of SIRT1 in the process of autophagy, and affect the occurrence and development of diseases.