STAT3 and cancer: For instance, SIRT1 exerts antiproliferative effects via the AMPK/mTOR pathway in the context of mutant p53 in HCC cells.329 SIRT1 overexpression inhibits the proliferation of renal cancer cells, while inhibition of SIRT1 expression has the opposite effects.325 SIRT1 might serve an anticancer role in cancer cells by upregulating expression of downstream AMPK.330 SIRT1 also inhibits GC cell proliferation via the STAT3/matrix metalloproteinase (MMP)-13 signaling pathway.331 SIRT1 has both promotive and inhibitory effects on proliferation in different cells.