Pyruvate dehydrogenase E1α, which is the primary link between glycolysis and the tricarboxylic acid cycle, is hyper-acetylated at lysine 385 in tubular epithelial cells after TGF-β1 stimulation and is regulated by SIRT3.906 With regard to SIRT6, a study investigated the effect of proximal tubule-specific SIRT6 KO on UUO-induced kidney tubulointerstitial inflammation and fibrosis which suggested that the SIRT6 activator MDL-800 mitigated UUO-induced kidney tubulointerstitial inflammation and fibrosis. The gene discussed is SIRT6; the disease is inflammation.