For example, SIRT1 inhibited drug-induced mitochondrial dysfunction and thus alleviated skeletal muscle atrophy by activating its downstream signaling PGC-1α.959 Moreover, SIRT2 effectively inhibited the autophagic flux, thus maintaining protein metabolism homeostasis in skeletal muscle.960 SIRT3-mediated cellular metabolism has an inhibitory effect in skeletal muscle atrophy. The gene discussed is SIRT3; the disease is Skeletal muscle atrophy.