BAX and central nervous system cancer: SIRT3 can stabilize Ku70–Bax interaction to enhance glioma cell viability.477 Moreover, SIRT7 affects the malignancy of glioma cells mainly by promoting glioma proliferation and invasion through ERK and STAT3 signaling.476 Evidence also suggests that SIRTs participate in the transformation of chemoresistance and radioresistance in glioma.