Expression of SIRT1 is upregulated by lncRNA MALAT1 via sponging miR-204, which might have a pivotal role in treatment and prognosis.375 Furthermore, SIRT1 promotes the migration of fibroblast-like synoviocytes in rheumatoid arthritis, which providing new insight into SIRT1 during RA progression. The gene discussed is MALAT1; the disease is rheumatoid arthritis.