TP53 and COVID-19: The unbalanced p53/SIRT1 axis might impact lymphocyte homeostasis in COVID-19 patients.649 COVID-19 can be characterized not only by an increase in p53 transcription in circulating lymphocytes, but also by a persistently activated p53 form, possibly due to the low level of SIRT1.649 Therefore, increased SIRT1 expression might help to alleviate the pathogenesis of COVID-19.