For example, SIRT1 is elevated in EC cell lines and tissues and SIRT1 promotes autophagy and proliferation of EC cells by reducing acetylation of LC3.272 The expression of SIRT2 is increased in most human EC cell lines and SIRT2 overexpression promotes EC cell proliferation but inhibits apoptosis.467 In contrast to SIRT1 and SIRT2, SIRT6 might function as a tumor suppressor of EC cells. The gene discussed is SIRT6; the disease is neoplasm.