SIRT5 and colorectal carcinoma: SIRT2-dependent IDH1 deacetylation regulates cellular metabolism and inhibits liver metastasis of CRC.381 SIRT4 upregulates E-cadherin expression and suppresses proliferation, migration and invasion through inhibition of glutamine metabolism in CRC cells.140 In addition to the anticarcinogenic effects of SIRTs, SIRT5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.449 SIRTs exert their regulatory function in CRC development through the modulation of several autophagy-related pathways.