Mechanistically, SIRT1 can resist the inflammatory response during IDD by inhibiting the transcriptional activity of NF-κB.58 Moreover, SIRT1 might inhibit disc degeneration by suppressing phosphorylation of activin 1 subunits c-Fos and c-Jun.953 It seems that SIRT1 might become a biological target for the treatment of IDD. The gene discussed is JUN; the disease is intervertebral disk degenerative disorder.