Global transcriptomics profiling by microarray in shBM and scramble control (shSC) C3H10T1/2 cells revealed, in addition to known clock-regulated metabolic and cancer-associated processes, enrichment of differentially regulated pathways related to cytoskeleton modulation, including focal adhesion, adherent junctions, actin cytoskeleton, and cytokine-receptor interaction (Figure 1B; Supplementary Figure S1B). Here, CLOCK is linked to cancer.