While MRTF/SRF suppresses beige adipogenesis, recent studies further demonstrated that MRTF/SRF activity was induced in HFD-induced obesity, promoting an adipogenic progenitor fate switch to fibrogenic lineage that predisposes to adipose fibrosis (McDonald et al., 2015; Lin et al., 2018). The gene discussed is SRF; the disease is obesity due to melanocortin 4 receptor deficiency.