FGFR3 and achondroplasia: Several missense variants of FGFR3 have been documented in genetic studies of patients with phenotypic disorders, such as achondroplasia (ACH), thanatophoric dysplasia I (TDI) and II (TDII), Muenke syndrome, hypochondroplasia (HCH), among others reported in the Human Gene Mutation database and also in tumors listed in the Catalogue Of Somatic Mutations In Cancer (16).