Several missense variants of FGFR3 have been documented in genetic studies of patients with phenotypic disorders, such as achondroplasia (ACH), thanatophoric dysplasia I (TDI) and II (TDII), Muenke syndrome, hypochondroplasia (HCH), among others reported in the Human Gene Mutation database and also in tumors listed in the Catalogue Of Somatic Mutations In Cancer (16). Here, FGFR3 is linked to hypochondroplasia.