TNF and metabolic dysfunction-associated steatohepatitis: MSigDB-mediated predictive mapping of signaling perturbations that unify these pathways, and which remained consistently downregulated under both chow and NASH diet–fed conditions, included downregulated epidermal growth factor/epidermal growth factor receptor (EGFR), TNFα, IL-22, and NF-κB signaling (Fig. 5D).