Notably, several highly stable probes (ICC ≥0.75) found to be annotated to HLA-C, HLA-DPB1, and HLA-DPA1 were located far away (>1 Kb) from any of the IBD-associated GVs, did not associate with catalogued GVs, nor were identified as a potential GV by Gaphunter (Figure 9, C–E; Figure 11; and Supplementary Table 3), suggesting by default strong methylation stability over time. The gene discussed is HLA-DPA1; the disease is inflammatory bowel disease.