Among the many IBD-associated DMPs, we specifically zoomed in on VMP1 (cg12054453 and cg16936953) as well as RPS6KA2 (cg17501210), as they were identified in multiple IBD-EWAS,17,18,21 as well as shown found to be among the most significant IBD-associated DMPs in our meta-analysis.48 Here, RPS6KA2 is linked to inflammatory bowel disease.