PTGS2 and neoplasm: The importance of PGs and COX-2 in the formation and progression of gliomas has been suggested by early studies and correlations between increased PG synthesis and tumor grade have been observed as well.30, 31Although recent studies have reported significant relationships between shortened patient survival and elevated COX-2 expression in various cancers,32, 33, 34, 35to our knowledge, such a relationship between COX-2 expression and patient survival in gliomas has not been determined.