In the brain, COX-2 is located in neurons of the neocortex and hippocampus, and it could be induced by cell cytokines, growth factors, and tumor promoters.14, 15Since it is associated with carcinogenesis, oncogenesis, and tumor progression, COX-2 can act as a prognostic predictor in different human cancer types. The gene discussed is PTGS2; the disease is cancer.