Although the cellular mechanisms of epileptogenesis are not as well-known as the physiology of abnormal discharges during seizures, recently the interest in the role of inflammation in the pathogenesis of epilepsy has been frequently mentioned.4During seizures, while intracellular adenosine triphosphate (ATP) decreases, phospholipases activated by the increase of adenosine monophosphate (AMP), adenosine diphosphate (ADP), lactic acid, and calcium cause an increase in free fatty acids, resulting in an increase in inflammatory cytokines (especially IL-1, IL-6 and TNF alpha). Here, IL1B is linked to epilepsy.