Obesity is a well-established risk factor for developing endometrial cancer, more than any other cancer type.1Insulin resistance is responsible for releasing growth factors for cellular proliferation, higher levels of interleukins, tumor necrosis factors, and adipokines causing an obesity-related proinflammatory state, and high estrogen levels through increased aromatase activity in adipose tissue are proposed as contributors to the increased risk of developing endometrial cancer.2Endometrial cancer is known as a hormone-dependent type of cancer. The gene discussed is TNF; the disease is Obesity.