PGF and Hypertension: However, when there is an imbalance between these factors, poor implantation of the placenta or worsening of placental perfusion can occur, leading to a reduction in factors such as PlGF and VEGF and an increase in sFlt-1, causing endothelial inflammation and increasing the chances of developing preeclampsia.5Biomarker assessment may be an interesting way to adequately distinguish preeclampsia from other complications that can present with worsening proteinuria and hypertension.28