NEIL1 and liver cancer: Characterization of NEIL1 polymorphic variantsthat are found in East Asia revealed decreased activity in the P68Hand that the A51V was temperature sensitive, suggesting it may alsobe a pathologic variant.4 Although thesevariants occur at a low frequency in the general East Asian population,all three NEIL1 polymorphic variants were identified in a small cohortof early onset HCC patients from the Qidong province in China, thuspotentially linking NEIL1 variants with increased risk of liver cancer.