CRP and infection: The course of infection treatment will ascertain through the normalization of specific markers (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], and white blood cell count [WBC]), and the failure of antibiotic therapy will be defined as (1) recurrent infection with new positive cultures, (2) new sinus formation, (3) further surgical debridement, or (4) need for long-term antibiotic treatment for persistent symptoms.