GPT and Hyperbilirubinemia: We generated PRS of 46 blood and urine biomarkers based on UK Biobank data.5 Polygenic risk scores for direct bilirubin and ALT levels were associated with hyperbilirubinemia (OR, 1.11 [95% CI, 1.09-1.14]; meta-analysis P = 5.07 × 10−23) and elevated ALT and AST levels (OR, 1.08 [95% CI, 1.05-1.11]; meta-analysis P = 1.2 × 10−5) in our cohorts) (eFigure 3 in Supplement 1).