GPT and metabolic dysfunction-associated steatotic liver disease: Although we found that genetic risk factors for elevated bilirubin, ALT, and AST levels were also risk factors for treatment-associated elevations in these biomarkers, conflicting findings were reported for nonalcoholic fatty liver disease–associated SNVs and drug-induced liver injury.31 The PRS used in our study was derived from older adults and therefore may have performance limitations; however, it was still associated with elevated bilirubin, ALT, and AST levels in this pediatric cohort.