There is conflicting evidence whether IGHMBP2 is associated with IgA nephropathy.23,24 Polyethylene glycol conjugated (PEGylated) preparations of asparaginase (pegasparagase) were used in both AALL0232 and AALL0434,25 and presence of anti-PEG IgM has been shown to accelerate blood clearance of the PEGylated products.26,27 It is possible that rs12283870 influences hepatic toxicity by modifying exposure to asparaginase. This evidence concerns the gene CD40LG and IgA glomerulonephritis.