ASPG and IgA glomerulonephritis: There is conflicting evidence whether IGHMBP2 is associated with IgA nephropathy.23,24 Polyethylene glycol conjugated (PEGylated) preparations of asparaginase (pegasparagase) were used in both AALL0232 and AALL0434,25 and presence of anti-PEG IgM has been shown to accelerate blood clearance of the PEGylated products.26,27 It is possible that rs12283870 influences hepatic toxicity by modifying exposure to asparaginase.