ASPG and acute lymphoblastic leukemia: It has been proposed that l-carnitine be incorporated into ALL treatment to reduce hepatotoxic effects in adult ALL.18,19,20 However, in a mouse model, it did not reduce asparaginase-associated hepatotoxic effects.21IGHMBP2 was initially discovered to bind to the immunoglobulin mu chain switch (S mu) region,22 but its function related to IgM has not been well established.