Patients of African ancestry had a lower incidence of hyperbilirubinemia, even though they had a higher risk allele frequency for UGT1A1rs887829 and a lower frequency of the PNPLA3 risk allele; thus, we were unable to identify a genetic basis for their lower hyperbilirubinemia. Here, PNPLA3 is linked to Hyperbilirubinemia.