One previous report of DSP missense variants in patients with a clinical diagnosis of ARVC suggested a potential “hotspot” N-terminal region, with 8/17 (47%) missense variants localized to the N-terminal compared with 1/28 (4%) of controls (P<0.0008).33 Further, they concluded DSPtv were significantly more prevalent in ARVC cases than controls. The gene discussed is DSP; the disease is arrhythmogenic right ventricular cardiomyopathy.