The other disorders included pseudoxanthoma elasticum (n = 2), coagulation factor II disorder (n = 2), beta-thalassemia (n = 2), Fabry disease (n = 2), MELAS (n = 1 for each disease below), protein S deficiency, hereditary hemorrhagic telangiectasia (HHT), polycystic kidney disease (PKD), CADASIL2, moyamoya disease (MD), cerebral cavernous malformation (CCM), familial hyperlipidemia, and primary thrombocythemia. The gene discussed is PROS1; the disease is cerebral cavernous malformation.