Another 51-year-old woman with CADASIL syndrome of stroke and mild dementia carried heterozygous HTRA1 p.G276A, which was reported to be likely pathogenic to cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy type 2 (CADASIL2) (Lee et al. 2018). Here, HTRA1 is linked to cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2.