The other disorders included pseudoxanthoma elasticum (n = 2), coagulation factor II disorder (n = 2), beta-thalassemia (n = 2), Fabry disease (n = 2), MELAS (n = 1 for each disease below), protein S deficiency, hereditary hemorrhagic telangiectasia (HHT), polycystic kidney disease (PKD), CADASIL2, moyamoya disease (MD), cerebral cavernous malformation (CCM), familial hyperlipidemia, and primary thrombocythemia. This evidence concerns the gene PROS1 and famililal cerebral cavernous malformations.