NOTCH3 and cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1: Because NOTCH3 p.R544C is the leading hotspot in both familial stroke (15/161, 9.3%, in this study) and sporadic stroke patients in Taiwan (Wei et al. 2021), suspicious patients with CADASIL syndrome could be screened for NOTCH3 p.R544C by Sanger sequencing.