Numerous disorders with a genetic background such as previously mentioned 22q11.2 microdeletion syndrome, Burnside-Butler Syndrome (15q11.2 BP1-BP2 microdeletion) or 1q21.1 microduplication/microdeletion syndrome have been noticed to contribute to a higher risk of schizophrenia development. Here, IGFBP2 is linked to schizophrenia.