In this context, documentation of clonality of hematopoiesis by identification of MPN driver mutations, or other mutations associated with myeloid neoplasms (ASXL1, EZH2, TET2, IDH1/ IDH2, SRSF2, and SF3B1), support the diagnosis [56]. The gene discussed is ASXL1; the disease is myeloproliferative neoplasm.