Instead, Narayanan et al. showed that thrombocytopenia is associated with increases in total immunoglobulin M (IgM), antiplatelet IgM, and/or anti-PF4 IgM and that monocyte activation contributes to increased platelet sequestration in the spleen and liver, leading to decreased platelets in peripheral blood [90]. This evidence concerns the gene CD40LG and Thrombocytopenia.