Since downregulating LRP/LR with LRP mRNA‐targeting siRNA has been shown to have a significant therapeutic effect against various cancer types in vitro, this study included performing a transient transfection with LRP‐specific siRNA (RPSA siRNA) and subsequently evaluating the effect of the downregulation of LRP/LR on cell viability and apoptosis, migration potential, and telomerase activity. The gene discussed is RPSA; the disease is cancer.