Coupled with a preadipocyte depletion phenotype, lipodystrophy in HGPS has also been experimentally induced by the introduction of progerin expression into a subset of pre adipogenic cells in mice, which led to fibrosis, senescence, and macrophage infiltration, with the ultimate result of white fat depletion (Revêchon et al., 2017). This evidence concerns the gene LMNA and lipodystrophy.