For example, recent work showed that transcription of locus 8q24-derived oncogenic lncRNAs such as PCAT2 could recruit centromeric protein-A (CENP-A), a variant of Histone H3, promote the ectopic localization of CENP-A, and alter epigenetic memory at a fragile chromosomal site in human cancer cells (Arunkumar et al., 2022). The gene discussed is CENPA; the disease is cancer.